Ketoconazole is a p- glycoprotein inhibitor and can have serious interactions with other medications. Although only excreted in tiny amounts from breast milk, it should only be taken by a breastfeeding mother if essential. Ketoconazole should not be taken in pregnancy. It may exacerbate adrenal insufficiency ( Addison disease) Endocrine effects including enlarged breasts (in males), alopecia and impotence.
KETOCONAZOLE CREMA SKIN
Allergic skin rash including urticaria.Adrenal insufficiency: ketoconazole reduces the body's production of cortisol.Abnormal liver function tests (15%) severe hepatitis can occur in 1:10,000 patients.The main concern with ketoconazole is the risk of liver problems, usually after it has been taken for prolonged periods (weeks). The rest is eliminated in faeces and urine either unchanged or after conversion by the liver into inactive compounds. It takes three to ten hours for half of the medication to be cleared from the blood stream. It is bound to proteins such as albumin in the circulating blood and is widely distributed in body tissues. The oral medication is somewhat better absorbed when it is taken with a fatty meal or acidic drink (e.g. The dose in children is usually 50 mg per day for those weighing less than 20 kg and 100mg daily for those 20-40 kg.
Nail infections are treated for up to twelve months. The oral dose of ketoconazole in adults is 200 to 400 mg daily, taken for two to eight weeks (a single dose may be effective for pityriasis versicolor). Very high concentrations of the drug develop within the skin, so it is effective in treating superficial fungal infections. Ketoconazole reaches the surface of the skin through normal blood circulation, sweat and sebum (skin oils). As it may still be available elsewhere, information about the product is included below. Oral ketoconazole was discontinued in New Zealand 1 December 2013. They are subsidised on prescription, but can also be obtained over the counter at a chemist. Ketoconazole 2% Cream (Nizoral Cream®) daily and 2% Shampoo (Nizoral®, Sebizole®) twice weekly are used for seborrhoeic dermatitis, a common scaly rash affecting scalp and face. Ketoconazole is effective against a broad spectrum of fungi including: In New Zealand, it is available as shampoo and cream. Ketoconazole binds to the fungal p450 enzymes and stops the cells making ergosterol, the main component of the cell wall.
We cater to entire spectrum of pharmaceuticals trade starting from Wholesale, Tender, Supplies, Orphan Drugs, cold chain line, biologics, Bio-similar and name patient supplies.Ketoconazole is an imidazole medicine used to treat fungal infections. Provide high quality service with very competitive rates and standard quality. We have dedicated warehousing facility for storage of pharma products in compliance with GSTP with regular inspection and monitoring. This ethical business approach and passion for excellence has driven us to provide our clients with better quality products. Under the dynamic support of our Supplies, we have grown at a steady pace and achieved a distinct position in the market. Sourced from the trustworthy manufacturers and Vendors of the global market. We are quality conscious company and hence ensure that our products are in adherence to international quality standards. Leveraging on this, we are successfully catering to the diverse needs of pharmaceutical and healthcare sectors around the world. Over the year, we have developed intensive expertise in the domain, which allows us to supply vast range of products in numerous composition and formulations. Our product range comprises of Active Pharmaceutical Ingredients, Pharmaceutical Raw Materials, Drug Intermediates Cancer Injections & Vials, Pharmaceutical Drugs, and Oncology Drugs. Established in the year 2011, we, “ Dheer Healthcare Private Limited” are a reputed supplier, trader, Third Party Manufacturer and exporter of Pharmaceutical Medicines, Pharmaceutical Raw Materials, and Excipients & Intermediates.
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